The project set out to develop high-yielding maize hybrids (Zea mays L.) with desirable characteristics suitable for both commercial and small-scale farmers’ conditions in Mozambique, where only 3% of the total maize area (1.3 million hectares) is covered by hybrids. Maize hybrids, in a group of 191 three way and 185 double crosses, were generated from elite lines of the National Agronomic Research Institute (INIA) and evaluated for grain yield potential and other agronomic traits in the 2003/04 season on a maximum of five sites. The hybrids were split into three sets of 45 to 80 treatments each, including one to four checks, depending on the number of sites involved. An alpha-lattice design with two replications was used at all sites. The data were analysed using SAS software. The analysis showed that there were significant differences for grain yield and anthesis day for at least two sets of each type of hybrids in different sites. Thus the best high-yielding genotypes specific for particular environments were identified. For example, in Angonia, a high maize-potential area, a maximum yield of 7.81 t ha–1 for three-way-cross hybrids and 8.64 t ha–1 for double-cross were observed. Interactions between sites and varieties for grain yield and anthesis day were significant (p < 0.01 and p < 0.05) for two sets of three-way-cross hybrids. A group of genotypes of three-way-cross hybrids with stable yielding were identified across sites. No significant interactions were observed for double-cross hybrids. It is recommended that the selected seed hybrids be produced for evaluation and promotion under farmers’ conditions using mother-and-baby trials.